The insulin-like growth factor binding protein-2 (IGFBP-2) at 0.01 or 0.1 mu g/mL tended to enhance IGF-II uptake at the young CP but not the old CP or other brain tissues, whereas bovine serum albumin generally inhibited the uptake. These age-related
changes suggest that the normal autocrine/paracine role of IGF-II at the CP is attenuated with age.”
“Background. Adequate mobility is essential to maintain an independent and active lifestyle. The aim of this cross-sectional study is to examine the associations of age with temporal and spatial gait variables in a population-based sample of older people, and whether these associations are modified by sex.
Methods. find more Men and women aged 60-86 years were randomly selected from the Southern Tasmanian electoral roll (n = 223). Gait speed, step length, cadence, step width, and double-support phase were recorded with a GAITRite walkway. Regression
analysis was used to model the relationship between age, sex, and gait variables.
Results. selleck inhibitor For men, after adjusting for height and weight, age was linearly associated with all gait variables (p < .05) except cadence (p = .11). For women, all variables demonstrated a curvilinear association, with age-related change in these variables commencing during the 7th decade. Significant interactions were found between age and sex for speed (p = .04), cadence (p = .01), and double-support phase (p = .03).
Conclusion. Associations were observed between age and a broad range of temporal and spatial gait
variables in this study. These associations differed by sex, suggesting that the aging process may affect gait in men and women differently. These results provide a basis for further research into sex selleck chemicals llc differences and mechanisms underlying gait changes with advancing age.”
“Background. Inability to maintain balance while standing increases risk of falls in older people. The present study assessed whether center of pressure (COP) movement measured with force platform technology predicts risk for falls among older people with no manifest deficiency in standing balance.
Methods. Participants were 434 community-dwelling women, aged 63-76 years. COP was measured in six stances on a force platform. Following balance tests, participants reported their falls with 12 monthly calendars. Incidence rate ratios (IRR) with 95% confidence intervals (CI) were computed from negative binomial regression models. For the analysis, those with >= 1 fall indoors were coded “”indoor fallers,”" those with >= 1 fall outdoors, but no indoor falls, were coded “”outdoor fallers.”" Outcome in the models was number of falls. Analyses were repeated including only participants without fall history prior to follow-up.
Results. Among 198 fallers, there were 57 indoor and 132 outdoor fallers.