AFM photographs showed the sample surface roughness became worse after AC220 mw tensile fatigue and the largest surface undulation was as twice that of the unfatigued sample. SEM photographs showed that many micropores of 10(1)-10(2)

mn, a sort of defect, occurred on the cross section of samples after tensile fatigue. The surface roughness became weaker and the size of the micropore was reduced to a few to dozens of nanometers with the addition of antiaging agent N-(1,3-dimethyl butyl butyl)-N’-phenyl-p-phenylene diamine (4020); furthermore, the mechanical properties and dynamic viscoelastic properties in the later period of fatigue changed much. E’ decreased greatly and tan 6 increased obviously with the extension of fatigue. It indicated that 4020 was only effective in the early period of tensile fatigue. (C) 2009 Wiley Periodicals, Inc. J Appl Polym Sci 115: 3535-3541, 2010″
“Fluconazole resistance among Cryptococcus neoformans is unusual in post-transplantation patients. Voriconazole is a triazole agent with good JQ-EZ-05 manufacturer antifungal activity but also with drug-drug interactions because of potent inhibition of the P450 enzyme

system. The interaction with immunosuppressive agents, especially calcineurin inhibitors, is of concern in post-transplantation patients. We report the. first case of fluconazole-resistant

cryptococcal meningitis in a kidney transplant recipient successfully treated with voriconazole, but complicated with a raised serum PF 00299804 concentration of tacrolimus and hyponatremia after co-administration. A 43-year-old man with a history of renal transplantation and on long-term immunosuppressive agents, including mycophenolate and tacrolimus, suffered from recurrent cryptococcal meningitis. He was treated with amphotericin B-liposome for 24 days because of fluconazole resistance. However, cryptococci were still found in the cerebrospinal. fluid; oral voriconazole was substituted. Six days after co-administration of voriconazole and tacrolimus, the trough concentration of tacrolimus markedly increased and hyponatremia developed. A culture of the CSF did not yield growth of Cryptococcus. Conditions improved after the cessation of tacrolimus for three days followed by reducing the dosage of voriconazole and tacrolimus. When voriconazole is initially added, the dosage of tacrolimus should be reduced. Close monitoring of tacrolimus concentration and its adverse effects, including nephrotoxicity, hyperglycemia, hyperkalemia, and hyponatremia, are mandatory. (C) 2009 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.”
“Objective.