As Doggett et al. wrote, “The right type of product and the right formulation are critical for achieving a successful eradication.”[9] Unfortunately, the “world” of insecticides

is oversized, complex, and varies according to countries. All generalizations run the risk of having some part wrong. Physicians and others must know that pyrethroids are the most common insecticide and two formulations are available: volatile, against flying insects, and sticky, against walking insects, frequently sold as anti-roach insecticide. This EX-527 latter type of insecticide against bedbugs can only be applied to strategic points (eg, suitcase hinges, edges, surfaces, seams) and should kill the bedbugs, if they are not resistant.[9, 23, 31, 32] However, insecticides remain one of the most important control

methods. Resorting to a pest manager is recommended for any other local strategic insecticide use, but seems beyond the traveler’s objectives. No preventive measure is ideal. Henceforth, never being infested by bedbugs resembles “Mission Impossible” for a hotel or Fluorouracil purchase any other structure that frequently lodges people. Hotel owners and their customers must know that primary infestation cannot be fully avoided and is independent of the hygiene level. Basic preventive measures include: staff information, cleaning, renovation, and better bedbug detection.[31, 32] Daily cleaning of the sites (leaving no crannies, paneling, peeling wallpaper) combined with information campaigns for the housekeeping personnel can minimize the risk of infestation by increasing the chance of early discovery of recently arrived bedbugs.[33] Renovation aims eliminate a maximum of hiding and dark places, transform the room into an unfriendly environment for bedbugs in an area designed to facilitate their detection, and perform nonchemical eradication. Mattress covers can prevent mattress infestation and facilitate the fight against bedbugs. Some available methods enhance bedbug detection. Among them is the dog

trained to detect old bedbugs by sniffing their odor, but success relies on good training for the dog and the dog owner’s entomological knowledge.[9, 34] According to the authors, carton, CO2, methane, pheromone, and traps are considered more-or-less efficient.[35, 36] Nontargeted chemical prevention is poorly effective, and initiates, maintains, and accentuates insecticide resistance. The bedbug population is expanding exponentially worldwide. This hematophagous insect is highly detrimental to humans because of the dermatological manifestations caused by its bites and superinfection. Fortunately, no risk of vectorial transmission of infectious agents has yet been demonstrated.