Cancer Res 1998, 58: 1521–3.PubMed 42. Takeuchi H, Kuo C, Morton DL, Wang HJ, Hoon DS: Expression of differentiation melanoma-associated antigen genes is associated with favorable disease outcome in advanced-stage melanomas. Cancer Res 2003, 63: 441–8.PubMed 43. DiMaio D, Mattoon D: Selleckchem Adriamycin Mechanisms of cell transformation by papillomavirus E5 proteins. Oncogene 2001, 20: 7866–73.CrossRefPubMed 44. Ashby AD, Meagher L, Campo MS, Finbow ME: E5 transforming proteins of papillomaviruses do not disturb the activity of the vacuolar H(+)-ATPase. J Gen Virol 2001, 82: 2353–62.PubMed 45. Bravo IG, Crusius K, Alonso A: The E5 protein of the human papillomavirus type 16 modulates

composition and dynamics of membrane lipids in keratinocytes. Arch Virol 2005, 150: 231–46.CrossRefPubMed 46. Suprynowicz FA, Disbrow

GL, Krawczyk E, Simic V, Lantzky K, Schlegel R: selleck inhibitor HPV-16 E5 oncoprotein upregulates lipid raft components caveolin-1 and ganglioside GM1 at the plasma membrane of cervical cells. Oncogene 2008, 27: 1071–1078.CrossRefPubMed 47. Kivi N, Greco D, Auvinen P, Auvinen E: Genes involved in cell adhesion, cell motility and mitogenic signaling are altered due to HPV 16 E5 protein expression. Oncogene 2008, 27: 2532–41.CrossRefPubMed 48. Watabe H, Valencia JC, Yasumoto K, Kushimoto T, Ando H, Muller J, Vieira WD, Mizoguchi M, Appella E, Hearing VJ: Regulation of tyrosinase processing and trafficking by organellar pH and by proteasome activity. J Biol Chem 2004, Selleckchem Staurosporine 279: 7971–81.CrossRefPubMed 49. Lewis C, Baro MF, Marques M, PIK-5 Grüner M, Alonso A, Bravo IG: The first hydrophobic region of the HPV16 E5 protein determines protein cellular location and facilitates anchorage-independent

growth. Virol J 2008, 5: 30.CrossRefPubMed Competing interests The authors declare that they have no competing interests. Authors’ contributions FDD prepared the viral strains and conduced the molecular analysis and helped in coordinating the work. CF participated in data analysis and interpretation and in manuscript preparation. CB and MP have been involved in western blot analysis, enzymatic assays and data interpretation. FP and SM participated in cell culture and cellular work and helped with viral strain preparation. CC participated in study design and critical revision of the manuscript. RC participated in the study design and coordination and helped to revise the manuscript. FDM conceived of the study, participated in its design and coordination, has been involved in data analysis and interpretation and helped to draft the manuscript. All authors read and approved the final manuscript.”
“Background Bladder cancer is the second most common urologic malignancy and accounts for approximately 90% of cancers of the urinary tract. Is the fourth most incident cancer in male and ninth in females [1].