J Biol Chem 1993, 268:14850–14860.PubMed 63. Cypess AM, Lehman S, Williams G, Tal I, Rodman D, Goldfine AB, Kuo FC, Palmer EL, Tseng YH, Doria A, Cypess AM, Lehman S, p38 MAPK signaling Williams G, Tal I, Rodman D, Goldfine AB, Kuo FC, Palmer EL, Tseng YH, Doria A, Kolodny GM, Kahn CR: Identification and importance of brown adipose tissue in adult humans. N Engl J Med 2009, 360:1509–1517.PubMedCentralPubMedCrossRef 64. Valle A, Catala-Niell

A, Colom B, Garcia-Palmer FJ, Oliver J, Roca P: Sex-related differences in energy balance in response to caloric restriction. Am J Physiol Endocrinol Metab 2005, 289:E15–22.PubMedCrossRef 65. Harper ME, Dent R, Monemdjou S, Bezaire V, Van Wyck L, Wells G, Kavaslar GN, Gauthier A, Tesson F, McPherson R: Decreased mitochondrial proton leak and reduced expression of uncoupling protein 3 in skeletal muscle of obese diet-resistant women. Diabetes 2002, 51:2459–2466.PubMedCrossRef 66. Chaston TB, Dixon JB, O’Brien learn more PE: Changes in fat-free mass during significant weight loss: a systematic review. Int J Obes 2007, 31:743–750. 67. Garthe I, Raastad T, Refsnes PE, Koivisto A, Sundgot-Borgen J: Effect of two different weight-loss rates on body composition and strength and power-related performance in elite athletes. Int J Sport Nutr Exerc Metab 2011, 21:97–104.PubMed 68. Rodriguez NR, Di Marco

NM, Langley S, American Dietetic A, Dietitians of C, American College of Sports M: American College of Sports Medicine position stand. Nutrition and athletic performance. Med Sci Sports Exerc 2009, 41:709–731.PubMedCrossRef 69. Burke LM, Loucks AB, Broad N: Energy and carbohydrate for training and recovery. J Sports Sci 2006, 24:675–685.PubMedCrossRef 70. Paddon-Jones D, Westman E, Mattes RD, Wolfe RR, Astrup A, Westerterp-Plantenga M: Protein, weight management,

and satiety. Am J Clin Nutr 2008, 87:1558S-1561S.PubMed 71. Dirlewanger M, di Vetta V, Guenat E, Battilana P, Seematter G, Schneiter P, Jequier E, Tappy L: Effects of short-term carbohydrate or fat overfeeding on energy expenditure and plasma leptin concentrations in healthy female subjects. Int J Obes Relat Metab Disord 2000, 24:1413–1418.PubMedCrossRef 72. Chin-Chance C, heptaminol Polonsky KS, Schoeller DA: Twenty-four-hour leptin levels respond to cumulative short-term energy imbalance and predict subsequent intake. J Clin Endocrinol Metab 2000, 85:2685–2691.PubMed 73. Jenkins AB, Markovic TP, Fleury A, Campbell LV: Carbohydrate intake and short-term regulation of leptin in humans. Diabetologia 1997, 40:348–351.PubMedCrossRef 74. Dulloo AG, Jacquet J, Girardier L: Poststarvation hyperphagia and body fat overshooting in humans: a role for feedback signals from lean and fat BMN 673 cost tissues. Am J Clin Nutr 1997, 65:717–723.PubMed 75. Dulloo AG, Jacquet J, Montani JP: How dieting makes some fatter: from a perspective of human body composition autoregulation. Proc Nutr Soc 2012, 71:379–389.PubMedCrossRef 76.