J Clin Endocrinol Metab 88:1658–1663PubMedCrossRef 12. Bravenboer N, Holzmann P, de Boer H, Roos JC, van der Veen EA, Lips P (1997) The effect of growth hormone (GH) on histomorphometric indices of bone structure and bone turnover in GH-deficient men. J Clin Endocrinol Metab 82:1818–1822, Erratum in: J Clin Endocrinol Metab 1997;82:2238PubMedCrossRef Napabucasin cell line 13. Conway GS, Szarras-Czapnik M, Racz K, Keller A, Chanson P, Tauber M, Zacharin M (2009) Treatment for 24 months with recombinant human GH has a beneficial effect on bone mineral density in young adults with childhood-onset GH deficiency. Eur J Endocrinol 160:899–907PubMedCrossRef 14. Growth Hormone Research Society

(1998) Consensus guidelines for the diagnosis and treatment of adults

with growth hormone deficiency: summary statement of the growth hormone research society workshop on adult growth hormone deficiency. J Clin Endocrinol Metab 83:379–381CrossRef 15. Bengtsson BA, Abs R, Bennmarker H, Monson TSA HDAC purchase JP, Feldt-Rasmussen U, Hernberg-Stahl E, Westberg B, Wilton P, Wüster C (1999) The effects of treatment and the individual responsiveness to growth hormone (GH) replacement therapy in 665 GH-deficient adults. KIMS Study Group and the KIMS International Board. J Clin Endocrinol Metab 84:3929–3935PubMedCrossRef 16. Jørgensen JT, Andersen PB, Rosholm A, Bjarnason NH (2000) Digital X-ray radiogrammetry: a new appendicular bone densitometric method with high precision. Clin Physiol 20:330–335PubMedCrossRef 17. Black DM, Palermo L, Sorensen T, Jørgensen

JT, Lewis C, Tylavsky F, Wallace R, Harris E, Cummings SR (2001) A normative reference Selleckchem GW 572016 database study for Pronosco X-posure System. J Clin Densitom 4:5–12PubMedCrossRef 18. Seeman E (2002) Pathogenesis of bone fragility in women and men. Lancet 359:1841–1850PubMedCrossRef 19. Ammann P, Rizzoli R (2008) Bone strength and its determinants. Osteoporos Int 14(suppl 3):13–18 20. Wang Q, Seeman E (2008) 2-hydroxyphytanoyl-CoA lyase Skeletal growth and peak bone strength. Best Pract Res Clin Endocrinol Metab 22:687–700PubMedCrossRef 21. Wang Q, Ghasem-Zadeh A, Wang XF, Iuliano-Burns S, Seeman E (2011) Trabecular bone of growth plate origin influences both trabecular and cortical morphology in adulthood. J Bone Miner Res 26:1577–1583PubMedCrossRef 22. Schweizer R, Martin DD, Schwarze CP, Binder G, Georgiadou A, Ihle J, Ranke MB (2003) Cortical bone density is normal in prepubertal children with growth hormone (GH) deficiency, but initially decreases during GH replacement due to early bone remodeling. J Clin Endocrinol Metab 88:5266–5272PubMedCrossRef 23. Bex M, Bouillon R (2003) Growth hormone and bone health. Horm Res 60(suppl 3):80–86PubMedCrossRef 24. Högler W, Briody J, Moore B, Lu PW, Cowell CT (2005) Effect of growth hormone therapy and puberty on bone and body composition in children with idiopathic short stature and growth hormone deficiency. Bone 37:642–650PubMedCrossRef 25.