Methods and results: In a population-based cohort of 64-year-old women, a group with IGT determined by repeated oral. glucose tolerance tests (n = 205) was compared

with healthy women with normal glucose tolerance (NGT, n = 188). Intima-media thickness (IMT) and plaques in selleck inhibitor the common carotid arteries (CCA) and bulbs were measured by ultrasound. The 95% confidence interval (CI) of the difference between the IGT and NGT groups was -0.03 to 0.03 mm. There was no difference in carotid bulb IMT or in the occurrence, size, and characteristics of plaques between the IGT and NGT groups. A meta-analysis was used to calculate summary measures of 12 reviewed studies showing a difference of 0.030 (95% CI 0.012-0.048) mm in carotid IMT between IGT and NGT groups. Heterogeneity in IMT differences between studies was shown.

Conclusions: In our population-based cohort of 64-year-old women, IGT was not associated with increased occurrence of subclinical atherosclerosis. However, a meta-analysis of 12 studies, including our current study, showed that IGT was associated

with a small increase in the CCA IMT. (C) 2008 Elsevier B.V. Alt rights reserved.”
“Background: While there are proponents of both bone-bridging and non-bone-bridging transtibial BIX 01294 molecular weight amputation techniques, there is a lack of evidence describing functional differences between these two techniques. The goal of the present investigation was to objectively compare the techniques of bone-bridging and non-bone-bridging with respect to limb socket displacement during physiologic loading.

Methods: Fifteen male subjects with an average age of twenty-seven years (range, twenty-two to thirty-two years) who had undergone

a unilateral transtibial amputation secondary to a traumatic wartime injury were prospectively evaluated. Seven patients had undergone a bone-bridging amputation, and eight had undergone a non-bone-bridging amputation. Digital fluoroscopic video was used to measure the vertical displacement of the limb within a total-surface-bearing Express-Pick?Library ������Ũ�� socket with weight-bearing from 0% to 100% of body weight.

Results: There was no difference in limb-socket displacement between amputation techniques with initial loading (12.78 mm for the bone-bridging group, compared with 12.43 mm for the non-bone-bridging group; p = 0.88) or with total loading (p = 0.98). Similarly, there was no difference between suspension mechanisms in limb-socket displacement with initial loading (12.15 mm for patients with pin lock suspension, compared with 12.98 mm for those with suction sleeve suspension; p = 0.72) or with total loading (18.24 mm for patients with pin lock suspension, compared with 21.42 mm for those with suction sleeve suspension, p = 0.21).

Conclusions: The current study demonstrated no difference between surgical techniques with respect to bone-socket displacement.