Microb Pathog 2004,36(5):237–245.PubMedCrossRef 10. Yarwood JM, Bartels DJ, Volper EM, Greenberg EP: Quorum sensing in Staphylococcus aureus biofilms. J Bacteriol 2004,186(6):1838–1850.PubMedCrossRef

11. Caiazza NC, O’Toole GA: Alpha-toxin is required for biofilm formation by Staphylococcus aureus. J Bacteriol 2003,185(10):3214–3217.PubMedCrossRef 12. Miller LS: Toll-like receptors in skin. Adv Dermatol 2008, 24:71–87.PubMedCrossRef 13. Lebre MC, van der Aar AM, van Baarsen L, van Capel TM, Schuitemaker JH, Kapsenberg ML, de Jong EC: Human keratinocytes express functional Toll-like receptor 3, 4, 5, and 9. J Invest Dermatol 2007,127(2):331–341.PubMedCrossRef 14. Olaru F, Jensen LE: Chemokine expression by human keratinocyte cell lines after activation of Toll-like receptors. Exp Dermatol 15. Niyonsaba F, Suzuki A, Ushio H, Nagaoka I, Ogawa selleck kinase inhibitor H, Okumura K: The human antimicrobial peptide dermcidin activates normal human keratinocytes. Br J Dermatol 2009,160(2):243–249.PubMedCrossRef 16. Menzies BE, Kenoyer A: Signal transduction and nuclear responses in Staphylococcus aureus-induced expression of human beta-defensin 3 in skin keratinocytes. Infect selleck chemicals Immun 2006,74(12):6847–6854.PubMedCrossRef 17. Kyriakis JM, Avruch J: Mammalian mitogen-activated

protein kinase signal transduction pathways activated by stress and inflammation. Physiol Rev 2001,81(2):807–869.PubMed 18. Johnson GL, Lapadat R: Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science 2002,298(5600):1911–1912.PubMedCrossRef 19. Karin M, Lawrence T, Nizet V: Innate immunity gone awry: linking microbial infections to chronic inflammation and cancer. Cell 2006,124(4):823–835.PubMedCrossRef 20. Kirker KR, Secor PR, James GA, Fleckman P, Olerud JE, Stewart PS: Loss of viability

and induction of apoptosis in human keratinocytes exposed to Staphylococcus aureus biofilms in vitro. Wound Repair Regen 2009,17(5):690–699.PubMedCrossRef 21. Heizmann CW, Cox JA: New perspectives on S100 proteins: a multi-functional Ca(2+)-, Zn(2+)- and Cu(2+)-binding protein family. PLEK2 Biometals 1998,11(4):383–397.PubMedCrossRef 22. Shimizu H, Banno Y, Sumi N, Naganawa T, Kitajima Y, Nozawa Y: Activation of p38 mitogen-activated protein kinase and caspases in UVB-induced apoptosis of human keratinocyte HaCaT cells. J Invest Dermatol 1999,112(5):769–774.PubMedCrossRef 23. Hildesheim J, Awwad RT, Fornace AJ Jr: p38 Mitogen-activated protein kinase inhibitor protects the epidermis against the acute damaging effects of ultraviolet irradiation by blocking apoptosis and inflammatory responses. J Invest Dermatol 2004,122(2):497–502.PubMedCrossRef 24. Shaw L, Golonka E, Osimertinib Potempa J, Foster SJ: The role and regulation of the extracellular proteases of Staphylococcus aureus. Microbiology 2004,150(Pt 1):217–228.PubMedCrossRef 25.