pylori eradication therapy could reduce the incidence of metachronous gastric cancers after endoscopic resection for early gastric cancer [29]. In this study, no difference was noted in the incidence of metachronous gastric tumors between gastric tumor patients in group A’ and non-A.

Although group A is generally regarded as low-risk group for gastric cancer, patients in group A’ may have a high risk of subsequent gastric tumor development. Because we clarified that most of the gastric tumor patients in group A were those with previous H. pylori infection, this result may indicate that H. pylori eradication therapy cannot always reduce the incidence of gastric tumor. Many of patients in group A’ had severe atrophic gastritis. Therefore, the incidence of gastric tumor in group A’ http://www.selleckchem.com/products/BIBW2992.html might be relatively high. Patients with a history of gastric tumors have

a high risk of subsequent gastric tumor development [8, 29] and evaluating cancer risk using ABC system is not suitable for these patients. Use of the ABC system to classify people into low-, intermediate-, and high-risk groups for gastric cancer is very effective, but U0126 clinical trial the inclusion of high-risk individuals as well as patients after H. pylori eradication therapy in group A is a key problem. To resolve this problem, new methods such as the discriminant function using serum markers for identifying patients are needed. No author has conflicts of interest or financial arrangements that could potentially influence the described research. Competing interests: the authors have no competing interests. “
“Recent studies have shown that patients with inflammatory bowel disease (IBD) are less likely to be infected with Helicobacter pylori compared with non-IBD patients. We aimed to study the prevalence of H. pylori-positive and H. pylori-negative gastritis in newly diagnosed children with IBD in comparison to those with non-IBD in Greece. All children who underwent first esophagogastroduodenal endoscopy between 2002 and 2011 were retrospectively Cepharanthine included. Four groups were studied: patients with Crohn’s disease (CD), ulcerative colitis (UC), IBD unclassified (IBDU), and non-IBD individuals (non-IBD).

Helicobacter pylori infection was defined by positive culture or by positive histology and CLO test. Those children with negative or not available culture and only one positive test (histology or CLO) were further evaluated by urea breath test, and the positives were also included in the infected group. We studied 159 patients with IBD (66 CD, 34 UC, and 59 IBDU) and 1209 patients in non-IBD individuals. Helicobacter pylori gastritis was less frequent in the IBD group (3.8% vs 13.2% in the control group, p < .001), whereas IBD patients were significantly older than non-IBD children (p < .001). Children with H. pylori-negative gastritis were 3.3 times more likely to belong in the IBD group compared with H. pylori-positive patients (p = .006). Occurrence of H.