References 1. U.S. find more Department of Health Services (2004) Bone health and osteoporosis: a report of the Surgeon General. U.S. Department of Health and Human Services, Rockville, MD, USA. http://www.surgeongeneral.gov/library/bonehealth. 2. Van Staa TP, Dennison EM, Leufkens HG, Cooper
C (2001) Epidemiology of fractures in England. Bone 29:517–522PubMedCrossRef 3. Tosteson AN, Burge RT, Marshall DA, Lindsay R (2008) Therapies for treatment of osteoporosis in US women: cost-effectiveness and budget impact considerations. Am J Manag Care 14:605–615PubMed 4. Bliuc D, Nguyen ND, Milch VE, Nguyen TV, Eisman JA, Center JR (2009) Mortality risk associated with low-trauma osteoporotic fracture and subsequent BI 2536 cost fracture in men and women. JAMA 301:513–521PubMedCrossRef 5. Ryg J, Rejnmark L, Overgaard S, Brixen K, Vestergaard P (2009) Hip fracture patients at risk of second hip fracture: a nationwide population-based cohort study of 169,145 cases during 1977–2001. J Bone Miner Res 24:1299–1307PubMedCrossRef TSA HDAC datasheet 6. Van Geel TA, van Helden S, Geusens PP et al (2009) Clinical subsequent fractures cluster in time
after first fractures. Ann Rheum Dis 68:99–102PubMedCrossRef 7. Huntjens KM, Kosar S, van Geel TA, Geusens PP, Willems P, Kessels A, Winkens B, Brink P, van Helden S (2010) Risk of subsequent fracture and mortality within 5 years after a non-vertebral fracture. Osteoporos Int (in press) 8. Cummings SR, Black DM, Thompson DE, Applegate WB, Barrett-Connor E, Musliner TA, Palermo L, Prineas R, Rubin SM, Scott JC, Vogt T, Wallace R, Yates AJ, LaCroix AZ (1998) Effect of alendronate on risk of fracture in women with low bone density but without vertebral
fractures: results from the Fracture Intervention Trial. JAMA 280:2077–2082PubMedCrossRef 9. Solomon DH, Avorn J, Katz JN, Finkelstein JS, Arnold M, Polinski JM, Brookhart MA (2005) Compliance with osteoporosis medications. Arch Intern Med 165:2414–2419PubMedCrossRef 10. Feldstein Cyclin-dependent kinase 3 AC, Weycker D, Nichols GA et al (2009) Effectiveness of bisphosphonate therapy in a community setting. Bone 44:153–159PubMedCrossRef 11. Kothawala P, Badamgarav E, Ryu S et al (2007) Systematic review and meta-analysis of real-world adherence to drug therapy for osteoporosis. Mayo Clin Proc 82:1493–1501PubMedCrossRef 12. Cramer JA, Roy A, Burrell A et al (2008) Medication compliance and persistence: terminology and definitions. Value Health 11:44–47PubMedCrossRef 13. Seeman E, Compston J, Adachi J et al (2007) Non-compliance: the Achilles’ heel of anti-fracture efficacy. Osteoporos Int 18:711–719PubMedCrossRef 14. Siris ES, Selby PL, Saag KG et al (2009) Impact of osteoporosis treatment adherence on fracture rates in North America and Europe. Am J Med 122:S3–S13PubMedCrossRef 15.