The above research work has been carried out with the aim of controlling the release of Cefditoren Pivoxil with sodium carbonate, carbopol, and sodium alginate. With the use of above mentioned excipients in different concentrations the gastro retentive effect was successful. The tablets were formulated by direct compression. All the physical parameters were in acceptable range as per the pharmacopeal specifications. Formulation F5 (20% carbopol, 6%sodium carbonate and 6% of sodium alginate) showed a good controlled release with better gastro retentive effect which was further confirmed by the swelling index.

Stability studies were performed for the formulation F5 as per the ICH guidelines. EGFR phosphorylation % Drug content at the 60th day was slightly reduced which may be further improved by adding suitable stabilizing agent. However further work is needed to establish regarding stability of the

tablets. All authors have none to declare. “
“Plant have known to serve mankind since ancient era with various biological activity among which antimicrobial activities using plant extracts have been well learn more reported.1 and 2 Such properties in plants are expressed due to the presence of active phytocomponents.3 and 4 With the emergence of multi drug resistant bacteria haunt for novel antibiotics has been upsurge in recent decades especially from natural reservoirs among which plants have been constant explored for antimicrobial agents due the fact that most of the plants are underscore toward isolating and characterization of novel natural products. Traditional out records have been well documented with various plants used as a sole source of herbal medicine against treating various diseases which is being still persist in various developing countries and has been followed by tribal communities in remote areas. Similarly excessive use of synthetic chemicals to improve crop productivity has created huge impact on all forms of life causing bio magnification.5 Hence to address these issues exploitation of plants which are under documented has gained tremendous progress across the globe. Antimicrobial

agents from plant source have given a new ray of hope against multi drug resistant microorganism compared to synthetic drugs which in turn has influenced the industrial funding for natural product-based drug discovery. Keeping these lacunae the present study was designed and executed toward exploiting aromatic herb Callistemon lanceolatus DC. as antibacterial activity. C. lanceolatus DC. belongs to a family Myrtaceae commonly known as crimson bottle brush, an aromatic evergreen shrub. 6 It is a hardy plant grows under a wide range of conditions and cultivated as ornamental plant. It grows to between 1 and 3 m in height and has leaves which are 3–7 cm long and 5–8 mm wide. The leaves are a tea substitute and have a delightfully refreshing flavor and tan dye is obtained.