In 32 patients, the presence of small-bowel neoplasm was confirmed. In 19 of these patients, the neoplasm was malignant. Sensitivity and specificity in the diagnosis of small-bowel neoplasms was 0.91 and 0.95, respectively, for reader 1 and 0.94 and 0.97, respectively, for reader 2; the kappa value was 0.95. Factors

associated with malignancy were the presence of longer solitary nonpedunculated lesions, mesenteric fat infiltration, and enlarged mesenteric lymph nodes.

Conclusion: Eighty-six of 91 studies were correctly interpreted, resulting in an overall diagnostic accuracy of 0.95 for MR enteroclysis in the detection of small-bowel neoplasms. (C) RSNA, 2010.”
“Leishmaniasis is a vector-borne protozoan infection with a wide clinical spectrum, which ranges from asymptomatic infection to fatal visceral leishmaniasis. A review of the recent literature indicates a sharp increase in imported leishmaniasis cases in developed, non-endemic countries Fludarabine concentration over the last decade, in association with increasing international tourism, military operations, and the influx of immigrants

from endemic countries. South America is LY411575 nmr the main area for the acquisition of cutaneous leishmaniasis, and adventure travelers on long-term trips in highly-endemic forested areas are at particular risk. Popular Mediterranean destinations are emerging as the main areas of acquisition of visceral leishmaniasis for European travelers. Leishmaniasis should be considered in patients presenting with a compatible clinical syndrome and a history of travel to an endemic area, even if this occurred several months or years ago. Appropriate counseling should be provided to adventure travelers, military personnel, researchers, and other groups of travelers likely to be exposed to sandflies in endemic areas. (C) 2010 International Society for Infectious Diseases.

Published by Elsevier Ltd. All rights reserved.”
“Purpose: To evaluate the feasibility of using computed tomographic (CT) colonography for preoperative examination of the proximal colon after metallic stent placement in patients with acute colon obstruction caused by colorectal cancer.

Materials and Methods: Institutional review board approval was obtained, and patient informed consent was waived. Fifty patients (mean age +/- standard deviation, 58.5 find more years +/- 11.7), who demonstrated no postprocedural complication after successful placement of self-expandable metallic stents to treat acute colon obstruction caused by cancer, underwent CT colonography 1-43 days (median, 5 days) after stent placement. CT colonography was performed after cathartic preparation by using magnesium citrate (n = 20) or sodium phosphate (n = 3), combined with oral bisacodyl, or by using polyethylene glycol (n = 27). Fecal/fluid tagging was achieved by using 100 mL of meglumine diatrizoate. The colon was distended by means of pressure-monitored CO(2) insufflation.

Hence, MI had no added value in this setting and standard LME modeling remains the method of choice. (C) 2012 Elsevier Inc. All rights reserved.”
“We present a 16-year-old girl who presented with chest pain. Given her obesity and positive family history,

she was felt to have atherosclerotic heart disease. However, an echocardiogram showed an atrial myxoma, which prompted surgical excision. This case supports the routine use of echocardiography and widened differential diagnosis when presented with pediatric chest pain.”
“Dubious data would lead to incorrect interpretations and consequently faulty conclusions. Environmental monitoring results therefore have to be unambiguous to avoid misunderstanding the problems under investigation. Representative sampling and appropriate laboratory procedures are keys to acquiring β-Nicotinamide concentration quality Nutlin-3a cost data in order to draw unbiased conclusions.

Although a large number of studies on organic pollutants have been published, few efforts have been directed towards

instituting a systematic framework from sampling design to instrumental analysis. Generally, the main components in such a framework should include sampling design, sample preparation, sample extraction, extract purification and fractionation, and quantification (including qualitative and quantitative analyses).

This review outlines the sampling and analytical framework appropriate for routine monitoring of organic pollutants, particularly persistent organic pollutants widely occurring in the environment. We emphasize statistically-based sampling schemes and quality-assurance and quality-control measures desirable for environmental monitoring programs.

By way of demonstrating their importance, we especially review procedures for collecting unconventional environmental samples (e.g., human blood, breast milk, human hair, fish and bird tissues, and ice

and snow) and analytical methods for typical emerging organic chemicals. (C) 2011 Elsevier Ltd. All rights reserved.”
“Background: Although administration of various stem cells has shown promise in stroke models, neural stem cells (NSCs) derived from human Ion Channel Ligand Library price induced pluripotent stem cells (iPSCs) have advantages over other cell types. We studied whether these cells could survive, differentiate, and improve stroke recovery in an ischemic stroke model. Methods: Human iPSCs were induced in vitro to an early NSC stage. One week after focal cerebral ischemia, 20 rats received cells or vehicle by intracerebral injection. Graft cell fate, infarct volume, and behavioral deficits were assessed. Results: Graft cells were found in 8 of the transplanted rats (80%), with estimated mean graft cell numbers nearly double the amount transplanted 1 month later.

Comprehensive cost-of-illness studies are needed to address data gaps in the published literature regarding the economic burden of iron overload. Comparative-effectiveness studies that evaluate clinical, economic and patient-reported outcomes would help the medical community

to better understand the value of different ICTs.”
“In this study, we investigate how the effect of L-arginine (ARG) and cyclodextrins upon omeprazole (OME) stability and solubility. The effect of the presence of ARG on the apparent selleck stability constants (K(1:1)) of the inclusion complexes formed between OME and each cyclodextrin, beta-cyclodextrin (beta CD), and methyl-beta-cyclodextrin (M beta CD) is studied by phase solubility diagrams and nuclear magnetic resonance (NMR) spectroscopy. The interaction of OME with those cyclodextrins, in the presence of ARG, is characterized using NMR spectroscopy and molecular dynamics simulations. ARG significantly increases the drug solubility

and complex stability, in comparison to inclusion complexes formed in its absence. The effect is more pronounced for the OME:beta CD complex. ARG also contributes to a larger stability of OME when Danusertib ic50 free in aqueous solution. The combination of ARG with cyclodextrins can represent an important tool to develop stable drug formulations.”
“A novel fluorinated epoxy compound, 4,4′-bis(2,3-epoxypropoxy-phenyl)-1-(3-trifluoromethylphenyl)-2,2,2-trifluoroethane (BEF), was synthesized starting from the coupling of phenol with 3′-trifluoromethyl-2,2,2-trifluroacetophenone catalyzed by Lewis acid to yield an intermediate compound, which was then converted to the fluorinated epoxy by epoxidation with epichlorohydrin. BEF could be thermally cured with organic anhydride or

aromatic amine as curing agents to produce thermally cured epoxy resins. Experimental results demonstrated that the thermally cured fluorinated epoxy resins showed good thermal stability with decomposition temperature at 5% weight loss of 342-364 degrees C in nitrogen, high glass transition temperature (T(g)) of 165-171 degrees C (determined by DMA), and outstanding mechanical properties with flexural strengths of 79-119 MPa, flexural moduli of 2085-2130 MPa. The thermally cured fluorinated epoxy resins also exhibited excellent electric Selleck INCB018424 insulating properties with volume resistivity of 1.59-9.23 10(16) Omega cm and surface resistivity of 4.81 x 10(15)-7.70 x 10(16) Omega. The dielectric constants at 1 MHz were measured in the range of 3.1-3.4 and the dielectric dissipation factor (tan delta) in the range of 1.38-2.48 x 10(-3). It was found that the fluorinated epoxy resins have improved electric insulating and dielectric properties as well as lower moisture adsorption compared with the corresponding commercial Bisphenol A type epoxy resins. (C) 2010 Wiley Periodicals, Inc.

The reaction proceeds in tetrachloromethane at 80-85A degrees C over 8 h.”
“OBJECTIVES: Hydroxychloroquine is an antimalarial agent that has been used in systemic lupus erythematosus and rheumatoid

arthritis treatment for many years. https://www.selleckchem.com/products/Vorinostat-saha.html Recently, novel mechanisms of action have been proposed, thereby broadening the therapeutic perspective of this medication. The purpose of this study was to evaluate the immunomodulatory activity of hydroxychloroquine in T helper 17 (Th17) cytokines in healthy individuals and patients.

METHODS: Eighteen female patients with systemic lupus erythematosus (mean age 39.0 +/- 12.9 years) and 13 female patients with rheumatoid arthritis (mean age 51.5 +/- 7.7 years) were recruited from Universidade Federal de Pernambuco-Brazil. The patients were included after fulfilling four classification criteria for systemic lupus erythematosus or rheumatoid arthritis from the American College of Rheumatology. After being stimulated with phorbol 12-myristate 13-acetate and ionomycin in the absence or presence of different concentrations of hydroxychloroquine, the interleukin 6, 17 and 22 levels were quantified with an enzyme-linked immunosorbent assay in culture supernatants of peripheral blood mononuclear cells from healthy individuals and patients.

RESULTS: We demonstrated that in peripheral blood mononuclear cells from healthy volunteers and in systemic Alisertib cell line lupus

erythematosus and rheumatoid arthritis patients, there was a significant reduction in the IL-6, IL-17 and IL-22 supernatant levels after adding hydroxychloroquine.

CONCLUSIONS Our in vitro results demonstrated that hydroxychloroquine inhibits IL-6, IL-17 and IL-22 production and contributes to a better understanding of the mechanism of action of this medication.”
“This paper presents the NOURISHING framework of food policies to promote healthy diets, and uses

the framework to summarize the policy actions taken by the Bellagio meeting countries. NOURISHING was developed by WCRF International to formalize a comprehensive policy package that brings together the key domains of action and policy areas. It aims to provide global level recommendations for a comprehensive response, within which policymakers have the flexibility to select specific policy selleck chemicals options suitable for their national/local contexts and target populations. It also aims to provide a framework for reporting, categorizing and monitoring policy actions taken around the world, and for systematically categorizing, updating, interpreting and communicating the evidence for policy to policymakers. In this paper we explain the structure for NOURISHING and the rationale behind it. We also use the framework to report on and categorize the policy actions implemented in the Bellagio countries.”
“Laryngomalacia is a common source of stridor and can lead to significant upper airway obstruction and feeding disturbances in infants.

In male dogs, a single subcutaneous dose of acyline safely and reversibly decreased serum gonadotrophins and testosterone concentrations for 9 days and prevented physiological response of gonadal the axis to agonistic challenge for 14 days. The same protocol reversibly impaired spermiogenesis, spermatocytogenesis and semen quality in both cats and dogs. In females, third-generation GnRH antagonists prevented ovulation and interrupted pregnancy in canids but not Ulixertinib manufacturer in felids. During anestrus, a single acyline injection exhibited

limited prevention of the flare-up effect in GnRH agonist-implanted bitches. Although GnRH antagonists appear to have a promising future in domestic carnivores reproduction, the information is still scarce and further work is needed before they can be widely recommended.”
“The physiological role of synaptic zinc has remained largely enigmatic since its initial detection in hippocampal mossy fibers over 50 years ago. The past few years have witnessed a number of studies highlighting the ability of zinc ions to regulate ion channels and intracellular signaling pathways implicated in neuroplasticity, and others that shed some light on the elusive role of synaptic zinc in learning and memory. Recent behavioral studies using knock-out mice for the synapse-specific zinc transporter

ZnT-3 indicate that vesicular zinc is required for the formation of memories dependent on the hippocampus and the amygdala, two brain centers that are prominently innervated by zinc-rich fibers. A common theme emerging from this research is the activity-dependent regulation of the Erk1/2 mitogen-activated-protein kinase pathway by synaptic Vorinostat nmr zinc through diverse mechanisms in neurons. Here we discuss current knowledge on how synaptic zinc may play a role in cognition through its impact on neuronal signaling.”
“Aims Diastolic dysfunction following myocardial infarction is an important predictor of outcome, irrespective

of left ventricular systolic function. Previous studies suggest that phosphordiesterase-5 inhibition has a favorable effect on the myocardium as well as on the pulmonary and systemic vasculature. Methods Patients 50 years old with recent myocardial infarction, PI3K inhibitor preserved left ventricular ejection fraction (45%), and echocardiographic evidence of diastolic dysfunction (ratio between early [E] transmitral filling velocity and early diastolic tissue Doppler velocity [e] 8 and left atrial volume 34 mL/m2) will be double-blindly randomized 1:1 to receive 9 weeks of treatment with 40 mg sildenafil, 3 times per day, or comparable placebo. Before randomization and after 9 weeks of treatment, resting Doppler echocardiography, resting right heart catheterization, and symptom-limited supine cycle exercise testing with simultaneous echocardiography and right heart catheterization will be performed. The primary end point is filling pressure at rest and at peak exercise.

01), and the LDA were more physiologic at final follow-up. Of the 67 cases, there was no segmental instability, and the bone fusion rate was 100%. One patient required revision open ACDF due to adjacent segment disc herniation 6 years postoperatively. There were no intraoperative complications,

dysphasia or esophageal injury in this study group. It indicated endoscopic technique for ACDF can obtain satisfactory results in patients with cervical disc herniation, cervical myelopathy, or radiculopathy. Compared with a traditional approach, this technique may be associated with less morbidity while improving cosmesis and postoperative recovery. Prospective randomized control trials are needed to directly compare these two procedures.”
“The iScore is a validated tool to estimate outcomes after an acute ischemic GSK1838705A cost MCC950 molecular weight stroke. A previous study showed the iScore can predict clinical response and risk of intracerebral hemorrhage (ICH) after administration of tissue plasminogen activator (tPA). We applied the iScore (www.sorcan.ca/iscore) to participants in the National Institute of Neurological Disorders and Stroke tPA stroke trials to evaluate its ability to estimate clinical response and

risk of ICH after thrombolysis. Based on results from our previous study, patients were stratified a priori into iScore <200 and iScore >= 200. The main outcome measure was ICH. Secondary outcomes included favorable composite outcome (defined as a modified Rankin Scale score of 0 or 1, National Institutes of Health Stroke Scale score <= 1, Barthel Index >= 95, or Glasgow Outcome Scale,1 at 3 months) and functional outcomes. The iScore was calculated in all 624 patients enrolled in the trial. The cohort comprised 507 patients (81%) with an iScore <200 and 117 (19%) with an iScore >= 200. An iScore >= 200 was associated with greater risk of symptomatic ICH in the tPA

group compared with the placebo group (15.4% v 3.9%; P = .04). Similar findings were found for ICH of any type (30.8% v 11.5%; P = .014), with higher ICH mortality (69.2% v 23.8%; P < .001). Despite the higher favorable composite outcome of tPA therapy in patients with an iScore <200 (58.7% v 41.9%; P BYL719 PI3K/Akt/mTOR inhibitor < .001), this therapy had no benefit in patients with an iScore <200 (15.4% v 13.4%; P = .77). In patients receiving tPA in the National Institute of Neurological Disorders and Stroke trial, the iScore estimated the clinical response and risk of hemorrhagic complications. Further prospective studies are needed before a change in practice can be recommended.”
“Objective: Evaluation and validation of the psychometric properties of the eight-item modified Medical Outcomes Study Social Support Survey (mMOS-SS).

Study Design and Setting: Secondary analyses of data from three populations: Boston breast cancer study (N = 660), Los Angeles breast cancer study (N = 864), and Medical Outcomes Study (N = 1,717).

Sessions were delivered by a trained promotora (community health worker), in partnership with a counselor. Sixty participants completed measures of cancer knowledge and self-efficacy preceding (pre-test) and following the intervention (post-test). Results From pre-test to post-test, the percentage of questions answered correctly about cancer knowledge increased (p<0.001), as did ratings of self-efficacy (p<0.001). Decreases were seen in Do not know’ responses for cancer knowledge (p<0.01), with a negative correlation between number of Do not knows’ on cancer

knowledge at pre-test and ratings of self-efficacy at pre-test (r=0.47, p<0.01). Conclusions When provided an accessible format, co-survivors of cancer from GSK3326595 underserved populations increase their cancer knowledge and self-efficacy. This is notable because research indicates that family members and friends with increased cancer knowledge assume more active involvement in the cancer care of their loved ones. Copyright (c) 2011 John Wiley & Sons, Ltd.”
“Ellis-Van Creveld syndrome or chondroectodermal dysplasia is a form of short-limbed dwarfism that affects the skeleton Crenigacestat and skin appendages. Disproportionate dwarfism, postaxial polydactyly, ectodermal dysplasia, a small chest, and a high frequency of congenital heart defects characterize

this autosomal recessive syndrome. Metabolic consequences of chondroectodermal dysplasia have not been reported previously from India. We report a case of chondroectodermal dysplasia associated RG-7388 chemical structure with metabolic disturbances qualifying a diagnosis of syndrome X. To our knowledge, this association has not been previously reported in the medical literature, and helps to unravel the metabolic association of this disorder.”
“Neurological manifestations caused by neuroinvading pathogens are typically attributed to penetration of the blood-brain barrier (BBB) and invasion of the central nervous system. However, the mechanisms used by many pathogens (such as Borrelia) to traverse the BBB are still unclear. Recent studies revealed that microbial

translocation across the BBB must involve a repertoire of microbial-host interactions (receptor-ligand interactions). However, the array of interacting molecules responsible for the borrelial translocation is not yet clearly known. Pathogens bind several host molecules (plasminogen, glycosaminoglycans, factor H, etc.) that might mediate endothelial interactions in vivo. This review summarizes our current understanding of the pathogenic mechanisms involved in the translocation of the BBB by neuroinvasive pathogens.”
“Background The present study assessed the feasibility of delivering peer support for couples coping with prostate cancer within a trial design. Methods/Design Ten peer volunteers completed training in research protocols and delivering tele-based couples support to men with prostate cancer and their partners.

Long-term knowledge was assessed by comparing scores as students advanced in grade from year 1 to 2 of the program (K to first, first to second, etc.). At six schools during year 2, pedestrian behavior was measured through direct observation of

children on city streets before and after administering the program. The project was approved by university and school board institutional review boards.

Results: During the 2 years, 1,564 students from nine schools were educated. this website In both years of the program, students in all grades had a significant gain in test scores immediately after and at 3 months compared with baseline knowledge. In contrast, only students moving from grade 3 to 4 demonstrated long-term retention (K -> 1: 7.7 vs. 6.7; grade 1 -> 2: 7.8 vs. 6.7; grade 2 -> 3: 7.3 vs. 6.8; grade 3 -> 4: 7.1 vs. 8.0; all p < 0.05 year 2 pretest vs. year 1 3-month posttest; analysis of variance and generalized linear model). Only 30% of children walk with an adult. Direct observation showed 64% of children stopped at the curb but only 8% looked left-right-left. Children walking alone were more likely to cross mid-block compared www.selleckchem.com/products/SB-525334.html with those walking with an adult (12% vs. 3%; p < 0.001) and also tend

to look left-right-left significantly more than those walking with an adult (67% vs. 20%; p < 0.0001).

Conclusions: A one-time annual educational program resulted in long-term knowledge retention between grades 3 and 4 only. In contrast, scores in younger grades reverted to baseline pretest values seen in year 1. Short-and intermediate-term knowledge gains were seen in all grades for both years. Because older children more often walk alone, we AMPK inhibitor postulate that the improved retention may be the result of repeated exposure and practice as a pedestrian. Cognitive knowledge did not appear to translate into improved pedestrian behavior. Walking with an adult also had a negative impact on observed pedestrian safety behavior.

The efficacy and impact of a one-time educational program may be insufficient to change long-term behavior and must be reevaluated.”
“Patients with branch atheromatous disease (BAD) are more likely to experience neurologic deficits compared with those with lacunar infarction (LI), although both disorders are forms of intracranial deep brain infarction. We clinically evaluated patients with BAD (n = 42) and LI (n = 57) to investigate why patients with BAD tend to experience progressing stroke. Patients presenting to our hospital with acute ischemic stroke between April 2008 and March 2009 were screened. LI was defined as an intracerebral lesion <15 mm in diameter and fewer than 3 slices or a lesion within the pontine parenchyma. BAD was defined as an intracerebral lesion of >= 15 mm in diameter and more than 3 slices or a lesion extending to the surface of the pontine base observed on diffusion-weighted magnetic resonance imaging.

The TMR ratio in MTJs with

Co2FeSi electrode is smaller than that of a MTJ with Co2MnSi electrode. Tunnel conductance characteristics were investigated, revealing no half-metallic character in MTJs with Co2FeSi electrode in the conductance-voltage curves. (C) 2009 American Institute of Physics. [DOI: 10.1063/1.3062814]“
“BACKGROUNDArabitol has many potential industrial applications and it can be produced by fermentation click here from glycerol, a major byproduct of biodiesel industry. This work aims at developing a new process for collecting and purifying arabitol from the broth of osmophilic Debaryomyces hansenii containing arabitol, unconsumed glycerol, and other minor impurities. RESULTS: The process developed and optimized in this study had the following steps: first, the broth supernatant was treated with 8gL(-1) activated carbon at 30 degrees C and pH 6 for removal of colored organics and some impurities. Then glycerol was selectively removed by acetone extraction at 30 degrees C. The acetone amount was optimized according to the measured solubility data of simulative glycerol-xylitol-acetone systems and real fermentation broth. The glycerol-removed CBL0137 remainder was next extracted for arabitol with butanol (90% of supernatant volume) at 90 degrees C. White arabitol crystals were collected from the cooled butanol extract. The overall recovery

and purity of arabitol crystals were 66% and 95%, respectively.

CONCLUSIONSuccessful arabitol purification was achieved with an optimized process. Fundamental phase equilibrium data of glycerol-xylitol-acetone systems were obtained. The process developed would prove valuable for arabitol production and potentially

for separation of other polyols. (c) 2012 Society of Chemical Industry”
“Applications of elemental cobalt are consequence of its phase-dependent magnetic properties; the Stem Cell Compound Library supplier anisotropic high-coercivity hcp-Co phase is preferred for permanent magnet applications, while the more symmetric low coercivity fcc- and pseudocubic epsilon-Co can be used in soft magnetic applications involving power electronics and magnetic write heads. The present work addresses the synthesis and characterization of nanocrystalline cobalt particles produced through a modified polyol-based approach conducive to the formation of fcc-, hcp-, or epsilon-Co phases. Metastable epsilon-Co and hcp-Co were exclusively formed in the presence of trimethylene glycol. In turn, fcc-Co or mixture of fcc/hcp-Co phases were produced in tetraethylene glycol. The average crystallite size in all cases ranged between 10 and 13 nm. Magnetic measurements confirmed the strong influence of synthesis conditions on crystal structure and hence on magnetic properties of nanocrystalline cobalt. The coercivity of the products varied from 338 to 550 Oe depending on the presence of the different cobalt structures. (C) 2009 American Institute of Physics. [DOI: 10.1063/1.

The apoptosis of HCCs was evaluated by in situ uptake of propidium iodide and Hoechst 33258. Protein expressions were detected by Western

blotting. Caspase-8 activity was measured using colorimetric method. To confirm the galangin-induced apoptotic pathway, inhibition of caspase-8 activity by Z-IETD-FMK, knockdown of Bid expression with siRNA, and overexpression of Bcl-2 in cells were carried out, respectively. The results show that galangin has significantly induced apoptosis in HCC lines. The caspase-8 is activated, and the cleavage of Bid results in the increase in tBid. The galangin-induced apoptosis is attenuated by Z-IETD-FMK, selleckchem Bid siRNA, and Bcl-2 overexpression, respectively. However, Bcl-2 fails to suppress caspase-8 activation and the cleavage of Bid. This study has demonstrated that galangin induces apoptosis in HCCs by activating caspase 8/t-Bid mitochondrial pathway. Although Bcl-2 overexpression attenuates galangin-mediated apoptosis of HCCs, it is not mediated

by the inhibition of FK228 tBid generation and caspase-8 activation.”
“Background: Prolonged QT interval associates with increased risk for sudden cardiac death after acute ischemic stroke. However, pathophysiology of prolonged QT interval after stroke is poorly elucidated. In this study, we investigated whether QT interval dynamics is different in patients with right and left middle cerebral artery (MCA) territory stroke. Method: Electrocardiogram (ECG) intervals were compared between baseline (retrieved retrospectively from medical records) and admission (acquired at the acute hospital admission) in 33 patients (65 +/- 9.5 years) with right or left MCA territory ischemic stroke. Head computed tomography (CT), cardiac ultrasound, and cardiac CT scans were undertaken. Results: Stroke Fosbretabulin was located in the right MCA territory in 21 (64%) and in the left MCA territory in 12 (36%) patients. Patients with right and left MCA stroke were similar with respect to time interval between baseline and

admission ECG recordings, positive history of heart disease, and left ventricular dimensions. Increase in heart rate-corrected QT interval (QTc) from baseline to admission was demonstrated to occur more often in patients with right (16 of 21; 76%) than in patients with left (3 of 12; 25%; P < .01) MCA stroke. Delta QTc between baseline and admission was significantly longer in patients with right (23 +/- 23 milliseconds) than in patients with left (-11 +/- 19 milliseconds; P < .0001) MCA stroke. Percent DQTc between baseline and admission was longer in patients with right (5.5% +/- 5.5%) than in patients with left (22.6% +/- 4.7%; P < .001) MCA stroke. Conclusions: Right MCA ischemic stroke results in prolongation of QT interval. Findings indicate cerebral asymmetry in brain-heart interaction during acute ischemic stroke.