The most common was allergy to proteins of wheat and rye There w

The most common was allergy to proteins of wheat and rye. There were no significant differences between the SCORAD, peripheral blood eosinophilia and total IgE in the study and control group. There was also more frequent sensitization to other inhalant and food allergens, allergic rhinitis and asthma in the investigated group of children.\n\nConclusions:\n\n1. Sensitization to cereal allergens is a common phenomenon in children with atopic dermatitis and should be taken into account in the diagnostic process.\n\n2. There was no relationship between the occurrence of sensitization to these allergens and the

severity of skin lesions assessed by the SCORAD scale.\n\n3. SCH 900776 in vivo For children who are allergic to cereal proteins, there is not predisposition to hypersensitivity to pollen allergens and rhinitis or bronchial asthma.\n\n4. In the case of positive results GSK621 nmr of allergy to cereal proteins and severe exacerbations of atopic dermatitis there should be considered some attempts of elimination and provocation tests.”
“Three lethality bioassays, using the salt-water crustacean Artemia salina Leach, Artemiidae, (conventional 96 microwell plate test and the Artoxkit M microbiotest) and the freshwater crustacean Thamnocephalus platyurus Packard, Thamnocephalidae, (Thamnotoxkit F microbiotest), were compared using extracts of ten Guatemalan

plant species. It was previously observed that five of them have anti-Artemia activity. These were: Solanum americanum Mill., Solanaceae, Gliricidia sepium (Jacq.) Kunth ex Walp., Fabaceae, Neurolaena lobata (L.) Cass., Asteraceae, Petiveria alliacea L., Phytolaccaceae, and Ocimum campechianum Mill., Lamiaceae. The five others: Curatella americana L., Dilleniaceae, Prunus barbata Koehne, Rosaceae, Quercus crispifolia Trel., Fagaceae, Rhizophora mangle L., Rhizophoraceae, and Smilax domingensis Willd., Smilacaceae, do not. All plants without anti-Artemia activity

had no lethal effects in both assays with A. salina. For the plants with anti-Artemia activity the Artoxkit M was not sensitive to G. sepium and the conventional Artemia test was not sensitive to S. americanum, G. sepium and GS-9973 nmr N. lobata. All the plant extracts, except for that of C. americana, had lethal effects on T. platyurus and the lethal median concentration (LC50) levels for this organism were in all cases substantially lower than those of the salt-water test species. This study revealed that T. platyurus is a promising test species worth further in depth investigation for toxicity screening of plant extracts with potential medicinal properties.”
“New oral anticoagulants (NOAC) inhibit factor Xa (Stuart-Prower factor) or factor IIa (thrombin) and are alternatives to vitamin K antagonists. Perioperative indications are deep vein thrombosis prophylaxis for prosthetic hip and knee replacement, therapeutic anticoagulation for deep vein thrombosis as well as the prophylaxis of stroke for patients with atrial fibrillation.

We have previously identified 13 H influenzae CRP sites that dif

We have previously identified 13 H. influenzae CRP sites that differ from canonical (CRP-N) sites in the following features: (1) Both half-sites of these noncanonical (CRP-S) sites have C-6 instead of T-6,

although they otherwise have an unusually high level of identity with the binding site consensus. (2) Only promoters with CRP-S sites require both the CRP and Sxy proteins for transcription activation. To study the functional significance of CRP-S site sequences, we purified H. influenzae (Hi)CRP and compared its DNA binding properties to those of the well-characterized E. coli (Ec)CRP. All EcCRP residues that contact DNA are conserved Selleck ABT-263 in HiCRP, and both proteins demonstrated a similar high affinity for the CRP-N consensus sequence. However, whereas EcCRP bound specifically to CRPS sites in vitro, HiCRP did

not. By systematically substituting base pairs in native promoters and in the CRP-N consensus sequence, we confirmed that HiCRP is highly specific for the perfect core sequence T(4)G(5)T(6)G(7)A(8) and is more selective than EcCRP at other positions in CRP sites. Even though converting C6,T6 greatly enhanced HiCRP binding to a CRP-S site, this had the unexpected effect of nearly abolishing promoter activity. A+ T-rich sequences upstream of CRP-S sites were also found to be required for promoter activation, raising the possibility that Sxy binds these A+T sequences to simultaneously enable CRP-DNA binding and assist in RNA polymerase recruitment. (C) 2008 Elsevier Ltd. All rights reserved.”
“To review the use Bafilomycin A1 in vivo of extracorporeal membrane oxygenation (ECMO) in severe paediatric pneumonia and evaluate factors that may affect efficacy of this treatment.\n\nRetrospective study of the ECMO database of a tertiary paediatric intensive care unit and chart review of all patients who were managed with ECMO during their treatment for severe pneumonia over a 23-year period. The main outcome measures CAL-101 mw were survival to hospital discharge, and ICU and hospital length of stay. We compared

the groups of culture-positive versus culture-negative pneumonia, venoarterial (VA) versus venovenous (VV) ECMO, community- versus hospital-acquired cases, and cases before and after 2005.\n\nFifty patients had 52 cases of pneumonia managed with ECMO. Community-acquired cases were sicker with higher oxygenation index (41.5 +/- A 20.5 versus 26.8 +/- A 17.8; = 0.031) and higher inotrope score [20 (5-37.5) versus 7.5 (0-18.8); = 0.07]. Use of VA compared with VV ECMO was associated with higher inotrope scores [20 (10-50) versus 5 (0-20); = 0.012]. There was a trend towards improved survival in the VV ECMO group (82.4 versus 62.9 %; = 0.15). Since 2005, patients have been older [4.7 (1-8) versus 1.25 (0.15-2.8) years; = 0.008] and survival has improved (88.2 versus 60.0 %; = 0.039).\n\nSurvival in children with pneumonia requiring ECMO has improved over time and is now 90 % in the modern era. Risk factors for death include performing a circuit change [odds ratio (OR) 5.

Knowledge of the advantages, limitations, and clinical role of

Knowledge of the advantages, limitations, and clinical role of www.selleckchem.com/products/ly2090314.html each equation

will facilitate their safe and effective use in drug dosing.”
“Enterovirus 71 (EV71) infection leading to cardiopulmonary failure (CPF) is rare, but usually fatal. In such cases, intensive cardiorespiratory support is essential for survival. In this study, we report our experience in the treatment of EV71-related CPF with extracorporeal life support (ECLS).\n\nThis was a retrospective study of a total of 13 children, aged 16 +/- A 10 months, with EV71-related hemodynamically unstable CPF, which was refractory to conventional treatments, who were rescued by transsternal ECLS from 2000 to 2008. The clinical manifestations and outcomes of the 13 children (present cohort) were compared with those of 10 children (past cohort) who had EV71-related CPF without ECLS between 1998 and 2000.\n\nAmong these 13 patients, 10 were successfully weaned off ECLS and survived. The myocardial recovery time was 71 +/- A 28 (median, 69) h, and the ECLS duration was 93 +/- A 33 (median, 93) h. Six surviving patients had a good neurological outcome at hospital discharge. All surviving patients had some neurological sequelae but showed improvement at follow-up, including dysphagia in nine, central hypoventilation in seven, limb weakness in six and seizure

in three. The present cohort had better neurological outcomes (46 vs. 0%, P = 0.005) and a higher survival rate (77 vs. 30%, P = 0.024) than the past cohort, respectively.\n\nPatients with EV71-related CPF supported by ECLS had a higher survival rate and fewer neurological

sequelae than those who only Duvelisib cost received conventional treatments. ECLS is an effective alternative method for treatment of children with refractory EV71-related CPF.”
“Phytoremediation is a plant based, cost effective technology to detoxify or stabilise https://www.selleckchem.com/products/acy-738.html contaminated soils. Fast growing, high biomass, perennial plants may be used not only in phytoremediation but also in energy production. Szarvasi-1 energy grass (Elymus elongatus subsp. ponticus cv. Szarvasi-1), a good candidate for this combined application, was grown in nutrient solution in order to assess its Cd, Cu, Ni, Pb and Zn accumulation and tolerance. Its shoot metal accumulation showed the order Pb < Ni < Cu similar to Cd < Zn. In parallel with this, Pb and Ni had no or very little influence on the growth, dry matter content, chlorophyll concentration and transpiration of the plants. Cu and Cd treatment resulted in significant decreases in all these parameters that can be attributed to Fe plaque formation in the roots suggested by markedly increased Fe and Cu accumulation. This came together with decreased shoot and root Mn concentrations in both treatments while shoot Cu and Zn concentrations decreased under Cd and Cu exposure, respectively. Zn treatment had no effect or even slightly stimulated the plants.

(c) 2013 Wiley Periodicals, Inc J Appl Polym Sci , 2013″

(c) 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013″
“In most methods for evaluation of

cardiac function based on echocardiography, the heart wall is currently identified manually by an operator. However, this task is very time-consuming and suffers from inter- and intraobserver variability. The present paper proposes a method that uses multiple features of ultrasonic echo signals for automated identification of the heart wall region throughout MDV3100 molecular weight an entire cardiac cycle. In addition, the optimal cardiac phase to select a frame of interest, i.e., the frame for the initiation of tracking, was determined. The heart wall region at the frame of interest in this cardiac phase was identified by the expectation-maximization (EM) algorithm, and heart wall regions in the following frames were identified by tracking each point classified in the initial frame as the heart wall region using the phased tracking method. The results for two subjects indicate the feasibility of the proposed method in the longitudinal axis view of the heart. (C) 2011 The Japan Society of Applied Physics”
“Germanium doped calcium borate glasses are investigated in term of thermoluminescence properties to seek their possibility to use as glass radiation dosimeter. The samples were exposed to 6 MV, and 10 MV photon beams in a dose range of 0.5-4.0 Gy. There is a single and broad thermoluminescence glow curve

that exhibits its maximum Nutlin-3 price intensity at about 300 degrees C. Linear dose response behavior has been found in this dose range for the both photon energies. Effective atomic number, TL sensitivity, and reproducibility have also

been studied. It is found that the sensitivity of germanium doped sample at 6 MV is only 1.28% and it is superior to the sensitivity at 10 MV. The reproducibility of germanium doped sample is good with a percentage of relative error less than 10%. The results indicate that this glass has a potential to be used as a radiation dosimety, especially for application in radiotherapy. (C) 2014 Elsevier B.V. All rights reserved.”
“This study employed rapid evaluation methods to investigate Selleckchem LB-100 how the leading industries of mining and tourism impact sustainability as manifest through social, economic and environmental dimensions in Yunnan, China. Within the social context, we also consider the differentiated impact on gender ratio-which is a salient feature of sustained development trajectories. Our results indicate that mining areas performed better than tourism areas in economic aspects but fell behind in social development, especially regarding the issue of gender balance. Conclusions on environmental status cannot be drawn due to a lack of data. The results from the environmental indicators are mixed. Our study demonstrates that rapid evaluation using currently available data can provide a means of greater understanding regarding local sustainability and highlights areas that need attention from policy makers, agencies and academia.

All rights reserved “
“Recurrent NAB2-STAT6 gene fusions hav

All rights reserved.”
“Recurrent NAB2-STAT6 gene fusions have recently Selleckchem MS-275 been identified in solitary fibrous tumour by next generation sequencing. Our aim was to examine the sensitivity and specificity of STAT6 immunohistochemistry for solitary fibrous tumour versus other morphologically similar soft tissue tumours. STAT6 expression was evaluated in 54 solitary fibrous tumours of various sites and 99 soft tissue tumours in

the histological differential diagnosis. We used a rabbit monoclonal STAT6 antibody (1: 100), which has not been reported by others, on formalin fixed, paraffin embedded whole sections and tissue microarray slides. Only nuclear staining of STAT6 was considered positive. Distribution of staining was scored as: 0 (no staining), 1+ (1-25%), 2+ (2650%), 3+ ( bigger than 50%). Intensity was scored as weak, moderate or strong. Nuclear STAT6 staining was present in all SFT cases tested (54/54, sensitivity 100%), regardless of histology, anatomical site or CD34 status. The majority of cases showed 3+ and strong staining. All tested cases of cellular angiofibroma (0/9), myofibroblastoma (0/10), spindle

cell lipoma (0/10), benign fibrous histiocytoma (0/13), dermatofibrosarcoma protruberans (0/9), low-grade fibromyxoid sarcoma (0/7), schwannoma (0/8), desmoid-type fibromatosis (0/8), monophasic synovial sarcoma (0/11), malignant peripheral nerve sheath tumour (0/7), and mesenchymal chondrosarcoma (0/7) were negative for STAT6 (specificity 100%). Our study further supports the utility of STAT6 immunohistochemistry Caspase inhibitor as an adjunct in the diagnosis of solitary fibrous tumour.”
“Recently, great progress has been made in particularly in the imaging of cartilage and bone structure. increased interest has focused on high-field (3 Tesla) imaging and more recently on ultra-high field (UHF) magnetic

resonance imaging (MRI) at 7 T for in vivo imaging. Because the signal-to-noise ratio (SNR) scales linearly with field strength, a substantial increase in SNR is expected compared with lower field strengths. This gain in SNR GDC-0941 concentration can be used to increase spatial resolution or reduce imaging time.\n\nThe goal of this review was to highlight recent developments and challenges in in vivo musculoskeletal (MSK) imaging using UHF-MRI at 7 T. One focus of this review is on the emerging methodology of quantitative MRI for the assessment of trabecular bone structure at the tibia, wrist, and knee. In particular for this application, Susceptibility effects between the bone and bone marrow transitions that scale with field strength have to be considered. Another important MSK application is the characterization of knee cartilage morphology. The higher SNR provided by UHF-MRI is a potential advantage for visualizing, segmenting, and analyzing cartilage. Standard clinical MSK imaging relies heavily on T1, T2, and proton density weighted fast spin echo sequences.


“Hepatocellular carcinoma has an increasing incidence and


“Hepatocellular carcinoma has an increasing incidence and high mortality. Treatment

options are limited if the disease is not diagnosed in its early stage. The natural course of the disease is aggressive but not always predictable. Molecular profiling is a promising tool for classification in order to optimize prognosis prediction and treatment for an individual patient. In the last decade a large amount of studies has been conducted to better classify hepatocellular carcinomas. The focus of this review is on implications of molecular classification for prognosis and therapeutic decision making in HCC patients. Most studies Selleckchem BI 2536 used microarray technique for genome wide profiling, but other methods to detect genomic changes and microRNA are gaining interest. The whole genome profiling studies identified differences in affected signalling and tried to relate this to prognosis. Some common subgroups were identified, such as the proliferation cluster and the beta-catenin cluster. However, there is still little overlap between most studies. Better

study design selleck products and bio-informatical analysis might help in this context. (C) 2011 Elsevier Ltd. All rights reserved.”
“Defective clearance of apoptotic cells has been shown in systemic lupus erythematosus (SLE) and is postulated to enhance autoimmune responses by increasing access to intracellular autoantigens. Until now, research has emphasized inherited rather than acquired impairment of apoptotic cell engulfment in the pathogenesis of SLE. In this study, we confirm previous results that efficient removal of apoptotic cells (efferocytosis) is bolstered in the presence of wild-type mouse serum, through the C3 deposition on the apoptotic cell surface. In contrast, sera from three mouse models of SLE, Mer(KD), MRL(lpr), and New Zealand Selleck SC79 Black/WF1 did not support and in fact actively inhibited apoptotic cell uptake. IgG autoantibodies were responsible for the inhibition, through the blockade of C3 recognition by macrophages. Consistent with this, IgG removal reversed

the inhibitory activity within autoimmune serum, and purified autoimmune IgG blocked both the detection of C3 on apoptotic cells and C3-dependent efferocytosis. Sera from SLE patients demonstrated elevated anti-C3b IgG that blocked detection of C3 on apoptotic cells, activity that was not found in healthy controls or patients with rheumatoid arthritis, nor in mice prior to the onset of autoimmunity. We propose that the suppression of apoptotic cell disposal by Abs against deposited C3 may contribute to increasing severity and/or exacerbations in SLE. The Journal of Immunology, 2011, 187: 2101-2111.”
“We have previously shown that mice lacking the IL-12-specific receptor subunit beta 2 (IL-12R beta 2) develop more severe experimental autoimmune encephalomyelitis than wild-type (WT) mice.

The catheter was positioned in front of the pulmonary vein ostia

The catheter was positioned in front of the pulmonary vein ostia. A pulmonary vein potential was demonstrated in 63.5% of the veins, which were disconnected with a mean of 1.6 radiofrequency applications with a mean time of 351 +/- 125.8 s (range 180-650) for each vein. Mean procedural time was 93 +/- 17.1 min (range 65-120), and fluoroscopy time was 13.7 +/- 4.0 (range 5-15) min. No complications occurred during and after or procedures.\n\nPulmonary veins disconnection

with MESH ablator catheter is feasible with short procedural and X-ray exposure time. Further studies are needed to compare this new device to standard multipolar mapping catheters in order to evaluate its ability to correctly identify pulmonary vein potentials and to selleck compound compare its safety and efficacy.”
“Selenium is an essential trace element for life, which can be toxic for humans GW4869 price when intakes reach a certain amount.

Therefore, since the margin between healthy intake and toxic intake is narrow, the selenium concentration of tap water is a parameter that must be monitored because of its potential for increased intake. The present work gives an overview of the different approaches used to calculate safe limits for selenium. As recommended by WHO, the guidelines for drinking water form the basis of national legislated standards for drinking water. Before setting a maximum acceptable level in drinking water, it is necessary to take into account the total intake of selenium in both food and beverage. The limit value of 10 mu gl(-1) FK228 mw for drinking water laid down in the European regulations for all countries should be adapted depending on geographic area, as previously recommended by WHO.”
“Metallic nanostructures are of immense scientific interest owing to unexpectedly

strong interaction with light in deep subwavelength scales. Resonant excitations of surface and cavity plasmonic modes mediate strong light localization in nanoscale objects. Nevertheless, the role of surface plasmon-polaritons (SPP) in light transmission through a simple one-dimensional system with metallic nanoslits has been the subject of longstanding debates. Here, we propose a unified theory that consistently explains the controversial effects of SPPs in metallic nanoslit arrays. We show that the SPPs excited on the entrance and exit interfaces induce near-total internal reflection and abrupt phase change of the slit-guided mode. These fundamental effects quantitatively describe positive and negative effects of SPP excitation in a self-consistent manner. Importantly, the theory shows excellent agreement with rigorous numerical calculations while providing profound physical insight into the properties of nanoplasmonic systems.”
“A new theory, to our knowledge, is developed that describes the dynamics of a lipidic pore in a liposome.


“Background: Group treatment is delivered in youth correct


“Background: Group treatment is delivered in youth correctional facilities, yet groups may be iatrogenic. Few measures with demonstrated psychometric properties exist to track behaviors of individuals during groups.

The authors assessed psychometrics for the Group Process-Individual Level measure (GP-IL) of group treatment. Methods: N = 152 teens were randomized to 1 of 2 groups (10 sessions each). Adolescents, counselors, and observers rated teen behaviors at sessions 3 and 10. GP-IL assesses reinforcement for deviancy and positive behaviors, member rejection, and counselor connection and praise. Results: Internal consistency and 1-month stability were demonstrated. Concurrent validity is supported by correlations with measures expected to be associated

with group behavior (e.g., coping skills). Counselors and observers rated more deviancy check details during interactive skills-building groups versus didactic psychoeducational groups (P smaller than = .005). Scales evidenced incremental validity. Conclusions: GP-IL offers a sound method of tracking adolescent behaviors for professionals working with groups. Counselors ratings were most reliable and valid overall.”
“Nuclear factors of activated T-cells (NFATs) are important regulators of the cytokine gene expression in activated T-cells. In the last decade, NFATs have been shown to regulate cell cycle, SYN-117 Metabolism inhibitor differentiation and apoptosis in cells of various origins revealing their importance for cell homeostasis. In this study, we investigated the effects of NFAT1 on proliferation and differentiation of v-myb-transformed BM2 monoblasts. In contrast to many other leukemic cell lines, BM2 cells do not respond to retinoic acid. However, once overexpressing NFAT1, they became sensitive to all-trans retinoic acid (ATRA). The ATRA-treated BM2NFAT1 cells differentiated

along ACY-241 purchase monocyte/macrophage pathway as evidenced by changes in cell morphology, adherence, phagocytic and non-specific esterase activities, reactive oxygen species production, and vimentin expression. Furthermore, overexpressed NFAT1 either alone or in combination with the ATRA-driven signalling pathway deregulated cyclin A and retinoic acid receptor proteins in BM2 cells. Data presented in this study indicate that the NFAT1 and ATRA signalling pathways synergize in control of proliferation and differentiation of BM2 monoblasts. (c) 2013 Elsevier Inc. All rights reserved.”
“We recorded brain activity when 21 subjects judged the beauty (aesthetic or affective judgment) and brightness (perceptual or cognitive judgment) of simultaneously presented paintings.

This case further emphasizes the capacity of pulmonary carcinoid

This case further emphasizes the capacity of pulmonary carcinoid tumor cells to show various morphologic expressions even toward a mesenchymal differentiation mimicking a synovial sarcoma.”
“Chronic microvascular compressions of the eighth nerve induce a slowing down of signal transmission in the auditory nerve, electrophysiologically characterized by IPL I-III prolongation.\n\nThe authors hypothesize this is compensated by an active slowing down of signal transmission of the contralateral input at the level of the brainstem, characterized by contralateral IPL III-V prolongation.\n\nDifferences between ipsilateral and contralateral IPL I-III and IPL III-V are analyzed

before and after microvascular decompression. ABR diagnostic criteria

for microvascular compression are ipsilateral IPL I-III prolongation or ipsilateral peak II www.selleckchem.com/products/azd1390.html decrease + ipsilateral IPL I-III prolongation. With IPL I-III as diagnostic click here criterion, unlike preoperatively the difference between the ipsi- and contralateral IPL I-III is significant postoperatively. When using the stricter diagnostic criterion of IPL I-III + peak II, there is a preoperative significant difference between ipsi- and contralateral IPL I-III, but postoperatively the difference between the ipsi- and contralateral IPL I-III is not significant.\n\nPreoperatively, there is a marginal significant difference between the ipsi- and contralateral IPL III-V, which disappears postoperatively.”
“Internal impingement is a term used to describe the pathologic contact of the undersurface of the rotator cuff with the glenoid. It typically occurs in overhead athletes, particularly throwers. In these athletes, the bones and soft tissues adapt to allow these athletes to have a supraphysiologic range of CFTRinh-172 concentration motion. In many athletes, these changes may lead to symptoms of internal impingement. This article discusses the background, biomechanics, pathophysiology,

clinical and radiographic assessment, treatments, and outcomes of this disorder.”
“PURPOSE\n\nThe quantitative relationship between tumor morphology and malignant potential has not been explored in liver tumors. We designed a computer algorithm to analyze shape features of hepatocellular carcinoma (HCC) and tested feasibility of morphologic analysis.\n\nMATERIALS AND METHODS\n\nCross-sectional images from 118 patients diagnosed with HCC between 2007 and 201 0 were extracted at the widest index tumor diameter. The tumor margins were outlined, and point coordinates were input into a MATLAB (Math-Works Inc., Natick, Massachusetts, USA) algorithm. Twelve shape descriptors were calculated per tumor: the compactness, the mean radial distance (MRD), the RD standard deviation (RDSD), the RD area ratio (RDAR), the zero crossings, entropy, the mean Feret diameter (MFD), the Feret ratio, the convex hull area (CHA) and perimeter (CHP) ratios, the elliptic compactness (EC), and the elliptic irregularity (El).


“Local

scour around complex piers under steady cle


“Local

scour around complex piers under steady clear-water condition was studied experimentally for a variety of configuration, including different sizes and shapes of complex piers. A total of 70 experiments were carried out. Three sets of experiments Selleck CH5183284 were performed over the entire range of possible pile cap elevations for complex piers with different geometrical characteristics. The collected data are used to quantify the pile cap elevations that maximize or minimize the local scour depth. Some of the available methodologies to estimate the maximum local scour depth around such complex piers are evaluated. The predictions of the scour depths improved by using the revised methods of Hydraulic Engineering Circular Number 18 and Coleman.”
“Researchers

are counting on comparative biologists to find alternative animal models of human Semaxanib aging that will foster experimental approaches to study disability-free longevity, not just the addition of years. This article presents one such alternative: the use of pet dogs living in the same environment as people to study the determinants of healthy longevity. There are both theoretical and practical reasons for this research model beyond the well-documented physiologic similarities between dogs and humans. First, a wealth of medical data-based on clinical and biochemical 5-Fluoracil purchase evaluation, medical imaging,

and pathology-is available for pet dogs. Second, a vast array of phenotypic domains can be accurately assessed in dogs, ranging from cardiac contractility and glomerular integrity to the ability to climb stairs and interact with people. Moreover, studying pet dogs obviates the purchase and per diem costs typically associated with large animal research. Pet dogs may be particularly well suited for exploring (1) mechanisms of sex differences in longevity; (2) interventions to compress morbidity and enhance healthspan; (3) genomic correlates of successful aging phenotypes and endophenotypes; (4) heterogeneity in resistance to aging-related diseases, such as cancer; and (5) noninvasive biomarkers of particular target organs. Finally, between-breed differences in senescence trajectories and longevity may expand hypotheses of key genetic factors that contribute to sustained organ function and the postponement of disease. Yet the pet dog paradigm in aging research is nascent; tapping into the potential of this model will add to the existing strengths of conventional model systems.”
“Pandanus amaryllifolius Roxb. has been identified as a rich source of principal basmati aroma compound 2 acetyl-1-pyrroline (2AP). An easy and efficient protocol for clonal propagation of P. amaryllifolius Roxb.